JD-5037

• Description :

  JD-5037 is a potent CB1R antagonist with an IC50 of 1.5 nM.

• CAS Number :

  [1392116-14-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Cannabinoid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/JD-5037.html

• Concentration :

  10mM

• Purity :

  99.38

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  NC([C@H](C(C)C)/N=C(NS(=O)(C1=CC=C(Cl)C=C1)=O)\N2N=C(C3=CC=C(Cl)C=C3)[C@@H](C4=CC=CC=C4)C2)=O

• Molecular Formula :

  C27H27Cl2N5O3S

• Molecular Weight :

  572.51

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Chorvat RJ. Peripherally restricted CB1 receptor blockers. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :4751-60.|[2]Knani I, et al. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. Mol Metab. 2016 Oct 22;5 (12) :1187-1199.|[3]Mukhopadhyay B, et al. Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology. 2015 May;61 (5) :1615-26.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CB1