IST5-002

• Description:

  IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 μM for Stat5a, 3.5 μM for Stat5b) . IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML) [1].

• Product Name Alternative:

  N6-Benzyladenosine-5'-phosphate

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H332, H335

• Target:

  Apoptosis; STAT

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ist5-002.html

• Concentration:

  10mM

• Purity:

  99.83

• Solubility:

  DMSO : 125 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)

• Smiles:

  O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)NCC4=CC=CC=C4)O1)O)O)O

• Molecular Formula:

  C17H20N5O7P

• Molecular Weight:

  437.34

• Precautions:

  H302, H315, H319, H332, H335

• References & Citations:

  [1]Zhiyong Liao, et al. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. Mol Cancer Ther. 2015 Aug;14 (8) :1777-93.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  STAT5

• CAS Number:

  [13484-66-7]