BigLEN (mouse)

• Description :

  BigLEN (mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. BigLEN (mouse) can be used to regulate responses associated with food intake and metabolism[1][2].

• UNSPSC :

  12352209

• Target :

  GPR171

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/biglen-mouse.html

• Purity :

  99.98

• Solubility :

  H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1[C@@H](CCC1)C(O)=O)[C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H]3N(CCC3)C([C@H](C)NC([C@H](CCC(N)=O)NC([C@H]4N(CCC4)C([C@H](CO)NC([C@H]5N(CCC5)C([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C78H130N24O22

• Molecular Weight :

  1756.01

• References & Citations :

  [1]Gomes I, et, al. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110 (40) :16211-6.|[2]Mack SM, et, al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10 (4) :1884-1891.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [501036-69-7]