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BigLEN (mouse)

CAT: 0804-HY-P2210-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2210-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BigLEN (mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. BigLEN (mouse) can be used to regulate responses associated with food intake and metabolism[1][2].
CAS Number
501036-69-7
UNSPSC
12352209
Target
GPR171
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/biglen-mouse.html
Purity
99.98
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(O)=O)[C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H]3N(CCC3)C([C@H](C)NC([C@H](CCC(N)=O)NC([C@H]4N(CCC4)C([C@H](CO)NC([C@H]5N(CCC5)C([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C78H130N24O22
Molecular Weight
1756.01
References & Citations
[1]Gomes I, et, al. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110 (40) :16211-6.|[2]Mack SM, et, al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10 (4) :1884-1891.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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