SEC

• Description :

  SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation[1][2].

• UNSPSC :

  12352005

• Target :

  Annexin A; Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cytoskeleton

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sec.html

• Concentration :

  10mM

• Purity :

  98.26

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(OCC)C1=CC(C2=CC=C(C=C2)OC)=NN1C[C@@H](COC3=CC=C(C=C3)Cl)O

• Molecular Formula :

  C22H23ClN2O5

• Molecular Weight :

  430.88

• References & Citations :

  [1]ShuYan Liu, et al. SEC-induced Activation of ANXA7 GTPase Suppresses Prostate Cancer Metastasis. Cancer Lett. 2018 Mar 1;416:11-23.|[2]ShuYan Liu, et al. A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4. Oncotarget. 2016 Mar 29; 7 (13) : 16282–16296.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1802997-81-4]