YM218 (free base)

• UNSPSC Description:

  YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease[1].

• Target Antigen:

  Vasopressin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/ym218-free-base.html

• Smiles:

  O=C(NC1=CC=C(C=C1)C(N2CCC(F)(/C(C3=CC=CC=C32)=C\C(N4CCC(CC4)N5CCCCC5)=O)F)=O)C6=C(OC=C6)C

• Molecular Weight:

  616.70

• References & Citations:

  [1]Tsukada J, et al. Pharmacologic properties of YM218, a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist[J]. Vascular pharmacology, 2005, 42(2): 47-55.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  387816-81-1