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YM218 (free base)

CAT: 0804-HY-118918Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118918Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease[1].
CAS Number
387816-81-1
UNSPSC
12352005
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ym218-free-base.html
Smiles
O=C(NC1=CC=C(C=C1)C(N2CCC(F)(/C(C3=CC=CC=C32)=C\C(N4CCC(CC4)N5CCCCC5)=O)F)=O)C6=C(OC=C6)C
Molecular Formula
C35H38F2N4O4
Molecular Weight
616.70
References & Citations
[1]Tsukada J, et al. Pharmacologic properties of YM218, a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist[J]. Vascular pharmacology, 2005, 42 (2) : 47-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
V1a Receptor ; V1b Receptor ; V2 Receptor

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