IL-17A, Mouse

• UNSPSC Description:

  IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases[1][2]. IL-17A Protein, Mouse is a recombinant mouse IL-17A protein and is expressed in E. coli. It consists of 137 amino acids (T22-A158).

• Type:

  Recombinant Proteins

• Assay Protocol:

  https://www.medchemexpress.com/cytokines/il-17a-protein-mouse.html

• Purity:

  98.0

• Smiles:

  TVKAAAIIPQ SSACPNTEAK DFLQNVKVNL KVFNSLGAKV SSRRPSDYLN RSTSPWTLHR NEDPDRYPSV IWEAQCRHQR CVNAEGKLDH HMNSVLIQQE ILVLKREPES CPFTFRVEKM LVGVGCTCVA SIVRQAA

• Molecular Weight:

  Approximately 16 kDa

• References & Citations:

  [1]Chen K, et al. Interluekin-17A (IL17A). Gene. 2017 May 30;614:8-14.|[2]Iwakura Y, et al. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev. 2008 Dec;226:57-79.|[3]Cua DJ, et al. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010 Jul;10(7):479-89.|[4]Wright JF, et al. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol. 2008 Aug 15;181(4):2799-805.|[5]Pelidou SH, et al. Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role. Exp Neurol. 2000 May;163(1):165-72.|[6]Liu Y, et al. IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011 Mar 1;186(5):3197-205.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Stored at -80°C for 1 year