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SNAI2 rabbit pAb

CAT: 0855-ES20439-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20439-01Size:50 µL
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Background
Snail family transcriptional repressor 2 (SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Description
Snail family transcriptional repressor 2 (SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008],
UniProt
O43623
Swiss Prot
O43623
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human SNAI2 AA range: 197-247
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm. Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Other Product Names
Zinc finger protein SNAI2 (Neural crest transcription factor Slug; Protein snail homolog 2)
Gene ID (Human)
6591

UniProtKB · O43623

Zinc finger protein SNAI2

SNAI2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43623
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SNAI2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R6P6, Q53FC1
Protein keywords

Cellular component

CytoplasmNucleus

Disease

DeafnessWaardenburg syndrome

Molecular function

Developmental proteinDNA-bindingRepressor

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation

PTM

Ubl conjugation

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