SNAT2 rabbit pAb

CAT: 0855-ES6652-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6652-01Size:50 µL
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Background
Enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline., function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta., induction:Up-regulated upon hypertonic conditions and amino acid deprivation., miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress., PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2., similarity:Belongs to the amino acid/polyamine transporter 2 family., subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity) . Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal., tissue specificity:Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level) .
Description
Enzyme regulation: Inhibited by N-methyl-D-glucamine and probably choline. function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1: 1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. induction: Up-regulated upon hypertonic conditions and amino acid deprivation. miscellaneous: Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress. PTM: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. similarity: Belongs to the amino acid/polyamine transporter 2 family. subcellular location: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
Product Name Alternative
SLC38A2; ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino a
UniProt
Q96QD8
Swiss Prot
Q96QD8
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC38A2. AA range:151-200
Target
SNAT2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
50kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
50kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity) . Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. .
Other Product Names
SLC38A2; ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino a
Gene ID (Human)
54407

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