RORγt Inverse agonist 3

RORγt Inverse agonist 3

• CAS Number: 2364429-77-4
• UNSPSC Description: RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively[1].
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ror-gamma-t-inverse-agonist-3.html
• Purity: 99.93
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(C)C1=NC2=C(C=CC=C2OCC3=C(Cl)C=CC(S(=O)(N4CCC[C@H]4C(NC)=O)=O)=C3Cl)C(C5=CN=CN5C)=C1
• Molecular Weight: 616.56
• References & Citations: [1]Amaudrut J, et al. Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1799-1806.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported