K6PC-5

• Description :

  K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research[1][2][3].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Filovirus; SphK

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Immunology/Inflammation

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/k6pc-5.html

• Purity :

  99.27

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCC(C(C(NC(CO)CO)=O)CCCCCC)=O

• Molecular Formula :

  C19H37NO4

• Molecular Weight :

  343.50

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48 (9) :1936-43. |[2]Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51 (2) :89-102.|[3]Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24 (4) :102266.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EBOV; SphK1

• CAS Number :

  [756875-51-1]