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K6PC-5

CAT: 0804-HY-124042-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124042-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research[1][2][3].
CAS Number
756875-51-1
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Filovirus; SphK
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/k6pc-5.html
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCC(C(C(NC(CO)CO)=O)CCCCCC)=O
Molecular Formula
C19H37NO4
Molecular Weight
343.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48 (9) :1936-43. |[2]Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51 (2) :89-102.|[3]Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24 (4) :102266.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EBOV; SphK1

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