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5-Methylcytidine 5′-triphosphate

CAT: 0804-HY-147338Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147338Size:1 Each
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Description
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) is a modified nucleoside triphosphates. 5-Methylcytidine 5′-triphosphate can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells[1].
CAS Number
327174-86-7
Product Name Alternative
5-Methyl-CTP
UNSPSC
12352005
Hazard Statement
H371
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-methylcytidine-5-triphosphate.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O[C@H]1N2C(N=C(N)C(C)=C2)=O
Molecular Formula
C10H18N3O14P3
Molecular Weight
497.18
Precautions
P260-P264-P270-P405-P501
References & Citations
[1]Shanmugasundaram M, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35 (7) :356-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-methyl-CTP
CAS Number327174-86-7
PubChem CID10207015
IUPAC Name[[(2R,3S,4R,5R)-5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular FormulaC10H18N3O14P3
Molecular Weight497.18
XLogP-5.8
Topological Polar Surface Area268
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count14
Rotatable Bond Count8
Heavy Atom Count30
Formal Charge0
Complexity900
SMILES
CC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
InChI
InChI=1S/C10H18N3O14P3/c1-4-2-13(10(16)12-8(4)11)9-7(15)6(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-7,9,14-15H,3H2,1H3,(H,20,21)(H,22,23)(H2,11,12,16)(H2,17,18,19)/t5-,6-,7-,9-/m1/s1
InChIKey
YIJVOACVHQZMKI-JXOAFFINSA-N
Chemical Structure
2D Structure
2D structure of 5-methyl-CTP
CAS: 327174-86-7
CID: 10207015
Formula: C10H18N3O14P3
MW: 497.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight497.18
XLogP3-5.8
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count14
Rotatable Bond Count8
Exact Mass497.00016325
Monoisotopic Mass497.00016325
Topological Polar Surface Area268 Ų
Heavy Atom Count30
Formal Charge0
Complexity900
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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