Dopal

• Description :

  Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species (ROS), and triggers aggregation of α-synuclein. Dopal elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  α-synuclein

• Type :

  Natural Products

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dopal.html

• Concentration :

  65.72 mM * 500 μL in Methanol

• Purity :

  90.0

• Smiles :

  O=CCC1=CC=C(O)C(O)=C1

• Molecular Formula :

  C8H8O3

• Molecular Weight :

  152.15

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9 (1) :42. |[2]Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5 (5) :1356-1367.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  α-synuclein Aggregation

• CAS Number :

  [5707-55-1]