Dopal

• Description:

  Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species (ROS), and triggers aggregation of α-synuclein. Dopal elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  α-synuclein

• Type:

  Natural Products

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dopal.html

• Concentration:

  65.72 mM * 500 μL in Methanol

• Purity:

  90.0

• Smiles:

  O=CCC1=CC=C (O) C (O) =C1

• Molecular Formula:

  C8H8O3

• Molecular Weight:

  152.15

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9 (1) :42. |[2]Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5 (5) :1356-1367.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  α-synuclein Aggregation

• CAS Number:

  5707-55-1