Dopal

• UNSPSC Description:

  Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species, and triggers aggregation of α-synuclein. DOPAL elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2].

• Target Antigen:

  Endogenous Metabolite; Reactive Oxygen Species; α-synuclein

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dopal.html

• Smiles:

  O=CCC1=CC=C(O)C(O)=C1

• Molecular Weight:

  152.15

• References & Citations:

  [1]Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9(1):42. |[2]Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5(5):1356-1367.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  5707-55-1