Products for Research Use Only
RegisterLogin

Dopal

CAT: 0804-HY-121252-01Size: 5 mg (65.72 mM x 500 μL in Methanol)Dry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-121252-01Size:5 mg (65.72 mM x 500 μL in Methanol)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species (ROS), and triggers aggregation of α-synuclein. Dopal elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2].
CAS Number
5707-55-1
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
α-synuclein
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dopal.html
Concentration
65.72 mM * 500 μL in Methanol
Purity
90.0
Smiles
O=CCC1=CC=C(O)C(O)=C1
Molecular Formula
C8H8O3
Molecular Weight
152.15
Precautions
H302, H312, H332
References & Citations
[1]Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9 (1) :42. |[2]Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5 (5) :1356-1367.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

Related Products

CatalogName
HY-113404-01DL-Dopa
HY-N0304-01L-DOPA
HY-W096171-01D-Dopa
HY-110286-016-Hydroxy-DOPA
HY-N0304S2-01L-DOPA-13C
HY-113404S1L-Dopa-d3
HY-113404S-01DL-Dopa-d6
HY-W387035D-α-Methyl DOPA
HY-N0304SL-DOPA-d6
HY-N0304S1-01L-DOPA-13C6

Alternative Products

CatalogName
sc-500914Dopal
CS-O-15473Dopal-d5
TRC-D533885-50MGDopal (>80%)
163954-01Dopal discontinued
D8999-01L-DOPA (Levodopa, L-dihydroxyphenylalanine, L-3-Hydroxytyrosine, 3-Hydroxy-L-tyrosine, (-) -3- (3,4-Dihydroxyphenyl) -L-alanine, Bendopa, Deadopa, Dopaflex, Dopal, Dopaidan, Dopalina, Dopar) discontinued. See 271132
D8999-02L-DOPA-2,5,6-d3 (Levodopd3, L-3-Hydroxytyrosine-d3, 3-Hydroxy-L-tyrosine-d3, (-) -3- (3,4-Dihydroxyphenyl-2,5,6-d3) -L-alanine, Bendopa-d3, Deadopa-d3, Dopaflex-d3, Dopal-d3, Dopaidan-d3, Dopalina-d3, Dopar-d3)
MBS6114997-01L-DOPA-2,5,6-d3 (Levodopd3, L-3-Hydroxytyrosine-d3, 3-Hydroxy-L-tyrosine-d3, (-)-3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine, Bendopa-d3, Deadopa-d3, Dopaflex-d3, Dopal-d3, Dopaidan-d3, Dopalina-d3, Dopar-d3)

Popular Products