D-α-Methyl DOPA

• Description :

  D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. D-α-Methyl DOPA occupies a pocket along the DQ8 peptide binding groove. D-α-Methyl DOPA inhibits the binding of a DQ8 peptide to an MHC class II molecule for presentation to CD4+ T cells, thereby slowing the development or progression of type 1 diabete or celiac disease[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H312-H332

• Target :

  MHC

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology; Metabolic Disease

• Smiles :

  OC1=CC(=CC=C1O)C[C@](N)(C)C(O)=O

• Molecular Formula :

  C10H13NO4

• Molecular Weight :

  211.21

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations :

  [1]Peter A, et al. Methods of treating autoimmune disease. WO2017165508A1. WIPO (PCT) . 2017-03-22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• Isoform :

  MHC II

• CAS Number :

  [2799-15-7]