D-Dopa

• UNSPSC Description:

  D-Dopa is a non-competitive, allosteric inhibitor for glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa exhibits good pharmacokinetic characteristics, and low blood-brain barrier permeability in mouse model[1].

• Target Antigen:

  Carboxypeptidase

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-dopa.html

• Purity:

  97.0

• Smiles:

  OC([C@H](N)CC1=CC(O)=C(C=C1)O)=O

• Molecular Weight:

  197.19

• References & Citations:

  [1]Gori SS, et al., D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics. 2022 Sep 23;14(10):2018.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  5796-17-8