D-Dopa

• Description :

  D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research[1][2][3].

• Product Name Alternative :

  3-Hydroxy-D-tyrosine

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Carboxypeptidase

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/d-dopa.html

• Purity :

  97.0

• Solubility :

  DMSO : 5 mg/mL (ultrasonic)

• Smiles :

  OC([C@H](N)CC1=CC(O)=C(C=C1)O)=O

• Molecular Formula :

  C9H11NO4

• Molecular Weight :

  197.19

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Gori SS, et al., D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics. 2022 Sep 23;14 (10) :2018. |[2]Karoum F, et al. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Res. 1988 Feb 2;440 (1) :190-4.|[3]Ogawa M, et al. L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro. J Infect Chemother. 2022 Mar;28 (3) :373-376.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [5796-17-8]