D-Dopa

• Description:

  D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research[1][2][3].

• Product Name Alternative:

  3-Hydroxy-D-tyrosine

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Carboxypeptidase

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-dopa.html

• Purity:

  97.0

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  OC ([C@H] (N) CC1=CC (O) =C (C=C1) O) =O

• Molecular Formula:

  C9H11NO4

• Molecular Weight:

  197.19

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Gori SS, et al., D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics. 2022 Sep 23;14 (10) :2018. |[2]Karoum F, et al. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Res. 1988 Feb 2;440 (1) :190-4.|[3]Ogawa M, et al. L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro. J Infect Chemother. 2022 Mar;28 (3) :373-376.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  5796-17-8