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D-Dopa

CAT: 0804-HY-W096171-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W096171-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research[1][2][3].
CAS Number
5796-17-8
Product Name Alternative
3-Hydroxy-D-tyrosine
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Carboxypeptidase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-dopa.html
Purity
97.0
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
OC([C@H](N)CC1=CC(O)=C(C=C1)O)=O
Molecular Formula
C9H11NO4
Molecular Weight
197.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Gori SS, et al., D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics. 2022 Sep 23;14 (10) :2018. |[2]Karoum F, et al. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Res. 1988 Feb 2;440 (1) :190-4.|[3]Ogawa M, et al. L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro. J Infect Chemother. 2022 Mar;28 (3) :373-376.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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