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L-DOPA-d6

CAT: 0804-HY-N0304SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0304SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-DOPA-d6 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease[1][2][3].
CAS Number
713140-75-1
Product Name Alternative
Levodopa-d6; 3,4-Dihydroxyphenylalanine-d6
UNSPSC
12352005
Target
Dopamine Receptor; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.48
Solubility
0.1 M HCl : 20mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C) |10 mM in DMSO|H2O : 1mg/mL (ultrasonic)
Smiles
OC([C@](N)([2H])C([2H])([2H])C1=C([2H])C(O)=C(C([2H])=C1[2H])O)=O
Molecular Formula
C9H5D6NO4
Molecular Weight
203.22
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38 (12) :2405-10.|[3]Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14 (4) :273-80. Epub 2007 Nov 7.|[4]Perez-Pardo P, et al. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2018 Aug 3;10:237.|[5]Park HJ, et al. Anti-allodynic effects of levodopa in neuropathic rats. Yonsei Med J. 2013 Mar 1;54 (2) :330-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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