DS-1558

• Description:

  DS-1558 is an orally active small molecule G protein-coupled receptor 40 agonist. DS-1558 not only increases the glucose-stimulated insulin secretion by glucagon like peptide-1 (GLP-1) but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats. DS-1558 is promising for research of type 2 diabetes[1].

• UNSPSC:

  12352005

• Target:

  G Protein-coupled Receptor Kinase (GRK)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ds-1558.html

• Smiles:

  FC(F)(C1=C2C([C@@H](CC2)OC3=CC=C(C=C3)[C@@H](OCC)CC(O)=O)=CC=C1)F

• Molecular Formula:

  C21H21F3O4

• Molecular Weight:

  394.38

• References & Citations:

  [1]Nakashima R, et al. Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists. Eur J Pharmacol. 2014 Aug 15;737:194-201.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1202575-67-4]