SC-514

• UNSPSC Description:

  SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

• Target Antigen:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SC-514.html

• Smiles:

  O=C(C1=C(N)C=C(C2=CSC=C2)S1)N

• Molecular Weight:

  224.30

• References & Citations:

  [1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278(35):32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  354812-17-2