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SC-514

CAT: 0804-HY-13802-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13802-01Size:5 mg
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Description
SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
CAS Number
354812-17-2
Product Name Alternative
GK 01140
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SC-514.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)C=C(C2=CSC=C2)S1)N
Molecular Formula
C9H8N2OS2
Molecular Weight
224.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278 (35) :32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β

Chemical Information

3-Amino-5-(3-thienyl)thiophene-2-carboxamide

3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide is a member of thiophenes and a ring assembly.

CAS Number354812-17-2
PubChem CID2807869
IUPAC Name3-amino-5-thiophen-3-ylthiophene-2-carboxamide
Molecular FormulaC9H8N2OS2
Molecular Weight224.3
XLogP2
Topological Polar Surface Area126
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count14
Formal Charge0
Complexity237
SMILES
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
InChI
InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)
InChIKey
BMUACLADCKCNKZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Amino-5-(3-thienyl)thiophene-2-carboxamide
CAS: 354812-17-2
CID: 2807869
Formula: C9H8N2OS2
MW: 224.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight224.3
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass224.00780523
Monoisotopic Mass224.00780523
Topological Polar Surface Area126 Ų
Heavy Atom Count14
Formal Charge0
Complexity237
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
FS27801-01SC 514
474184SC-514

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