SC-514

• Description:

  SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

• Product Name Alternative:

  GK 01140

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SC-514.html

• Purity:

  99.97

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(N)C=C(C2=CSC=C2)S1)N

• Molecular Formula:

  C9H8N2OS2

• Molecular Weight:

  224.30

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278 (35) :32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IKK-β

• CAS Number:

  [354812-17-2]