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Apoptosis inducer 24

CAT: 0804-HY-163923-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163923-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC50 of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD50 is 91.2 mg/kg) [1].
CAS Number
2763063-09-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-24.html
Smiles
O=C1C(C#N)=C[C@]2([C@]([H])(C1(C)C)CC[C@](C)(C2=CC3=O)[C@]4([C@]3([C@]5([C@@](C(OCCCCOC(C6=CC=C(C=C6)OCC7=CC=C(C=C7)B8OC(C)(C(C)(O8)C)C)=O)=O)(CC4)CCC(C)(C5)C)[H])[H])C)C
Molecular Formula
C55H70BNO9
Molecular Weight
899.96
References & Citations
[1]Li N, et al., New CDDO Arylboronate Ester Derivatives with High Selectivity and Low Toxicity. J Med Chem. 2024 Aug 22;67 (16) :14329-14344.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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