2′-Hydroxychalcone
CAT:
804-HY-W012349-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
2′-Hydroxychalcone
- CAS Number: 1214-47-7
- UNSPSC Description: 2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].
- Target Antigen: Apoptosis; Autophagy; Fungal; NF-κB
- Type: Reference compound
- Related Pathways: Anti-infection;Apoptosis;Autophagy;NF-κB
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer; Infection
- Assay Protocol: https://www.medchemexpress.com/2-hydroxychalcone-1.html
- Purity: 96.76
- Solubility: DMSO : 200 mg/mL (ultrasonic)
- Smiles: O=C(C1=C(O)C=CC=C1)/C=C/C2=CC=CC=C2
- Molecular Weight: 224.259
- References & Citations: [1]Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33. |[2]Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16(4):514.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported