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FPR-A14

CAT: 0804-HY-103472-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103472-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].
CAS Number
329691-12-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fpr-a14.html
Purity
98.58
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(OCO2)C2=C1)N/N=C/C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3
Molecular Formula
C23H20N2O5
Molecular Weight
404.42
Precautions
H315, H319, H335
References & Citations
[1]Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71 (4) :1061-74.|[2]Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14 (6) :e0217815.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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