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FPR2 agonist 5

CAT: 0804-HY-178144Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178144Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS -induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases[1].
UNSPSC
12352005
Target
Calcium Channel; Formyl Peptide Receptor (FPR) ; Interleukin Related; NO Synthase
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
N#CC1=CC=C(C[C@H](NC2=NN=C(C3=CC=C(F)C=C3)O2)C(N4CCC5=C4C=CC=C5)=O)C=C1
Molecular Formula
C26H20FN5O2
Molecular Weight
453.47
References & Citations
[1]Francavilla F, et al. Design, Synthesis, and Biological Evaluation of Novel Heteroaryl, Squaramide, and Indolcarboxamide Derivatives as Formyl Peptide Receptor 2 Agonists to Target Neuroinflammation. ACS Chem Neurosci. 2025 Sep 3;16 (17) :3292-3311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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