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FPR2 agonist 2

CAT: 0804-HY-144604-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144604-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPR2 agonist 2 is a potent and permeates the blood brain barrier FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1].
CAS Number
2829263-20-7
UNSPSC
12352005
Target
Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fpr2-agonist-2.html
Concentration
10mM
Purity
98.51
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C=C1)NC(N[C@H](C(N2CCC3=C2C=CC(F)=C3)=O)CC4=CC=C(C=C4)C#N)=O
Molecular Formula
C25H20F2N4O2
Molecular Weight
446.45
References & Citations
[1]Mastromarino M, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem. 2022; 65 (6) :5004-5028.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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