Bax agonist 1

• UNSPSC Description:

  Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research[1].

• Target Antigen:

  Apoptosis; Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bax-agonist-1.html

• Smiles:

  N12CN(CC2)CN(C3)CCN3C1

• Molecular Weight:

  168.24

• References & Citations:

  [1]Meiguo Xin, et al. Small-molecule Bax agonists for cancer therapy. Nature communications 5.1 (2014): 4935.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  18304-79-5