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Bax agonist 1

CAT: 0804-HY-119682Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119682Size:1 Each
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Description
Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM) . Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research[1].
CAS Number
18304-79-5
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bax-agonist-1.html
Smiles
N12CN(CC2)CN(C3)CCN3C1
Molecular Formula
C8H16N4
Molecular Weight
168.24
References & Citations
[1]Meiguo Xin, et al. Small-molecule Bax agonists for cancer therapy. Nature communications 5.1 (2014) : 4935.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax

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