RegisterLogin

CCKBR agonist-1

CAT: 0804-HY-P11540Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P11540Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP) . CCKBR agonist-1 can be used for the study of Alzheimer's disease[1].
CAS Number
[2923120-30-1]
UNSPSC
12352209
Target
Amyloid-β; Cholecystokinin Receptor; MMP
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC(Br)=CC=C3)C(N)=O)=O)=O)=O)C
Molecular Formula
C32H39BrN6O7
Molecular Weight
699.59
References & Citations
[1]Wang JL, et al. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2025 Nov 20:S0092-8674 (25) 01238-3.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
ADAM10; CCKBR

Related Products

CatalogName
HY-179721CCKBR agonist-2
HY-149941HNTS1R agonist-1
HY-156972NOP agonist-1
HY-149807TGR5 agonist 1
HY-159917PPL agonist-1
HY-149650TLR4 agonist-1
HY-142697SGC agonist 1
HY-163829TLR2 agonist 1
HY-155705BMP agonist 1
HY-147987FFA1 agonist-1

Alternative Products

CatalogName
PPL00214-2aPcDNA3.1 (+) -Flag-CCKBR
K6789202Cckbr sgRNA CRISPR Lentivector (Rat) (Target 1)
K4437902Cckbr sgRNA CRISPR Lentivector (Mouse) (Target 1)
PPL00214-3PPLK/GFP+Puro-CCKBR shRNA (3+1)
K0388202CCKBR sgRNA CRISPR Lentivector (Human) (Target 1)
K0388206CCKBR sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K6789206Cckbr sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K4437906Cckbr sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
MBS8577264-01CCKBR
YP-W71860-01Porcine CCKBR (CCKBR) ELISA Kit

Popular Products