TLR4-IN-1

• Description:

  TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models[1].

• UNSPSC:

  12352211

• Target:

  Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tlr4-in-1.html

• Smiles:

  O=C1C(C(C)CC1C(CC(C)=O)=O)=O

• Molecular Formula:

  C10H12O4

• Molecular Weight:

  196.20

• References & Citations:

  [1]Zhou S, et al., Design, Synthesis, and Antirheumatoid Arthritis Mechanism of TLR4 Inhibitors. ACS Omega. 2024 Aug 14;9 (34) :36232-36241.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2617578-93-3]