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TLR4-IN-2

CAT: 0804-HY-173388Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173388Size:1 Each
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Description
TLR4-IN-2 (Compound Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4-IN-2 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 23.2 µM. TLR4-IN-2 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4-IN-2 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders[1].
CAS Number
1019984-44-1
UNSPSC
12352005
Target
COX; JNK; NF-κB; NO Synthase; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=CC=C(C=C2C(C1C3=CC=C(C=C3)OC)C4=CC=CC=C4)OC
Molecular Formula
C23H20O3
Molecular Weight
344.40
References & Citations
[1]Tang ML, et al. Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. Eur J Med Chem. 2016 May 4;113:63-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2

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