CENP-E-IN-2

• Description:

  CENP-E-IN-2 (compound 3) is a photoswitchable CENP-E inhibitor, with the pIC50 of 6.82 without light illumination and 5.85 with 365 nm light illumination. CENP-E-IN-2 has antitumor activity[1].

• UNSPSC:

  12352005

• Target:

  Kinesin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cenp-e-in-2.html

• Smiles:

  ClC1=C (OC (C) C) C=CC (C (N[C@H] (C (NC) =O) CC2=CC=C (/N=N/C3=C (C) N (CCO) N=C3C) C=C2) =O) =C1

• Molecular Formula:

  C27H33ClN6O4

• Molecular Weight:

  541.04

• References & Citations:

  [1]Kazuya Matsuo, et al. A chemical platform for the efficient screening of arylazopyrazole-based photoswitchable CENP-E inhibitors using mild cyclization reactions. Bioorg Med Chem Lett. 2024 Jul 17:111:129892.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Kinesin-7/CENP-E