(E) -2-Hexadecenal

• Description:

  (E) -2-Hexadecenal (trans-2-Hexadecenal) is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E) -2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E) -2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways[1].

• Product Name Alternative:

  Trans-2-Hexadecenal

• UNSPSC:

  12352211

• Target:

  Apoptosis; JNK; Microtubule/Tubulin; Mixed Lineage Kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-2-hexadecenal.html

• Purity:

  99.9

• Smiles:

  CCCCCCCCCCCCC/C=C/C=O

• Molecular Formula:

  C16H30O

• Molecular Weight:

  238.41

• References & Citations:

  [1]Kumar A, et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul;23 (7) :1144-52.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  22644-96-8