(E)-2-Hexadecenal

(E)-2-Hexadecenal

• CAS Number: 22644-96-8
• UNSPSC Description: (E)-2-Hexadecenal is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways[1].
• Target Antigen: Apoptosis; JNK; Microtubule/Tubulin; Mixed Lineage Kinase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/e-2-hexadecenal.html
• Smiles: CCCCCCCCCCCCC/C=C/C=O
• Molecular Weight: 238.41
• References & Citations: [1]Kumar A, et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul;23(7):1144-52.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported