6-Hydroxy bexarotene

6-Hydroxy bexarotene

• CAS Number: 368451-07-4
• UNSPSC Description: 6-Hydroxy bexarotene is the main circulating metabolite of bexarotene, found in rats, dogs, and humans. Compared to the parent compound, 6-hydroxy-bexarotene shows a significantly reduced ability to bind to retinoid receptors and exhibits very minimal activity in activating retinoic acid receptors[1].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/6-hydroxy-bexarotene.html
• Smiles: CC1=CC2=C(C(C)(CC(C2(C)C)O)C)C=C1C(C3=CC=C(C=C3)C(O)=O)=C
• Molecular Weight: 364.48
• References & Citations: [1]S R Howell, et al. Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors. Drug Metab Dispos. 2001 Jul;29(7):990-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported