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Bexarotene-d4

CAT: 0804-HY-14171S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14171S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bexarotene-d4 is a deuterium labeled Bexarotene (LGD1069) . Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma[1][2][3][4][5].
CAS Number
2182068-00-2
Product Name Alternative
LGD1069 D4
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; RAR/RXR
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.51
Solubility
10 mM in DMSO|DMF : ≥ 20mg/mL|DMSO : ≥ 10mg/mL|Ethanol : ≥ 0.5mg/mL
Smiles
CC1(C2=C(C(C)(CC1)C)C=C(C(C(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C(O)=O)=C)=C2)C)C
Molecular Formula
C24H24D4O2
Molecular Weight
352.50
Precautions
H302
References & Citations
[1]Vakeva L, Ranki A, Hahtola S. Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland. Acta Derm Venereol. 2012 May;92 (3) :258-63. doi: 10.2340/00015555-1359.|[2]Gui Y, et al. Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1. J Pain. 2019 Jan 17. pii: S1526-5900 (18) 30607-2.|[3]Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P. Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphoma of the α/β Type with Bexarotene. Case Rep Dermatol. 2012 Jan;4 (1) :56-60.|[4]Orendas P, Kubatka P, Kajo K, Stollarova N, Kassayova M, Bojkova B, Pec M, Nosal V, Kiskova T, Zihlavnikova K, Karsnakova R. Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis. Neoplasma. 2012;59 (4) :469-74.|[5]Cras A, Politis B, Balitrand N, Darsin-Bettinger D, Boelle PY, Cassinat B, Toubert ME, Chomienne C.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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