Bexarotene

CAT: 0804-HY-14171-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14171-01Size:50 mg
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Description
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) [1][2][3]. Bexarotene can be used for the research of cutaneous T-cell lymphoma.
CAS Number
[153559-49-0]
Product Name Alternative
LGD1069
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Bexarotene.html
Purity
99.90
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
CC1(C2=C(C(C)(CC1)C)C=C(C(C(C3=CC=C(C=C3)C(O)=O)=C)=C2)C)C
Molecular Formula
C24H28O2
Molecular Weight
348.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Nathalia Rodrigues de Almeida, et al. A review of the molecular design and biological activities of RXR agonists. Med Res Rev. 2019 Jul;39 (4) :1372-1397.|[2]Danyang Shen, et al. Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer. Onco Targets Ther. 2019 Sep 24;12:7877-7886.|[3]Y Wang, et al. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene. 2006 Mar 2;25 (9) :1320-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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