Bexarotene

• Description:

  Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) [1][2][3]. Bexarotene can be used for the research of cutaneous T-cell lymphoma.

• Product Name Alternative:

  LGD1069

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; RAR/RXR

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Bexarotene.html

• Purity:

  99.90

• Solubility:

  DMSO : 60 mg/mL (ultrasonic)

• Smiles:

  CC1(C2=C(C(C)(CC1)C)C=C(C(C(C3=CC=C(C=C3)C(O)=O)=C)=C2)C)C

• Molecular Formula:

  C24H28O2

• Molecular Weight:

  348.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Nathalia Rodrigues de Almeida, et al. A review of the molecular design and biological activities of RXR agonists. Med Res Rev. 2019 Jul;39 (4) :1372-1397.|[2]Danyang Shen, et al. Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer. Onco Targets Ther. 2019 Sep 24;12:7877-7886.|[3]Y Wang, et al. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene. 2006 Mar 2;25 (9) :1320-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [153559-49-0]