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PTC-209

CAT: 0804-HY-15888-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15888-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs) . PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2].
CAS Number
315704-66-6
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Autophagy; BMI1
Type
Reference compound
Related Pathways
Autophagy; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PTC-209.html
Purity
99.76
Solubility
DMSO : ≥ 32 mg/mL
Smiles
CC1=C(C2=CSC(NC3=C(Br)C=C(OC)C=C3Br)=N2)N4C=CC=NC4=N1
Molecular Formula
C17H13Br2N5OS
Molecular Weight
495.19
Precautions
H315, H319, H320
References & Citations
[1]Kreso A, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014 Jan;20 (1) :29-36.|[2]Chen D, et al. Targeting BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. Cell Stem Cell. 2017 May 4;20 (5) :621-634.e6.|[3]Sulaiman S, et al. PTC-209 Anti-Cancer Effects Involved the Inhibition of STAT3 Phosphorylation. Front Pharmacol. 2019;10:1199. Published 2019 Oct 21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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