SMP-028

• Description :

  SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM.

• UNSPSC :

  12352005

• Target :

  Lipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/SMP-028.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC)NCCN1/C(SC=C1C2=CC=C(N3CCOCC3)C=C2)=N/C4=CC=CC(F)=C4

• Molecular Formula :

  C23H26FN5O2S

• Molecular Weight :

  455.55

• References & Citations :

  [1]Nishizato Y, et al. Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028--for human safety in clinical study. Toxicol Appl Pharmacol. 2014 May 1;276 (3) :213-9.|[2]Nishizato Y, et al. Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats. Toxicol In Vitro. 2014 Apr;28 (3) :397-402.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [914389-14-3]