PDE4B/D-IN-4

PDE4B/D-IN-4

• UNSPSC Description: PDE4B/D-IN-4 (compound 4p) is a potent inhibitor of PDE-4B and PDE-4D, with IC50s of 5.50 nM and 6.81 nM, respectively. PDE4B/D-IN-4 shows an increase in the level of intracellular cAMP[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4b-d-in-4.html
• Smiles: O=C(N/N=C/C1=CC=C(OC)C(O)=C1)C2=CC=C(OC(F)F)C(OCC3CC3)=C2
• Molecular Weight: 406.38
• References & Citations: [1]Ahmed M Moussa, et al. Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors. Bioorg Chem. 2024 Oct 24:153:107911
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported