PDE4B/7A-IN-1

PDE4B/7A-IN-1

• CAS Number: 2511632-25-8
• UNSPSC Description: 1 a /5-hydroxynitrile rubber 7 receptor antagonist (5-HT1 a k i = 8 nm, kb= 0.04 nm; 5-nitrile rubber 7K I = 451 nm, kb= 460 nm) has pde4b/pde7a inhibitory activity (PDE4B ic50= 80.4 μ M; Pde7a chip 50= 151.3 μ M）。 Compound 22 has a very good ability of passive penetration of biofilm and high metabolic stability in vitro. In addition, 22's pharmacological evaluation showed its pre cognitive and antidepressant properties in rat behavioral tests.
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/pde4b-7a-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(C=CC=C1)N2CCN(CC2)CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O
• Molecular Weight: 425.56
• References & Citations: [1]Jankowska A,et al. Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. Eur J Med Chem. 2020 Sep 1;201:112437.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported