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PDE4B/7A-IN-1

CAT: 0804-HY-146201Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146201Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4B/7A-IN-1 (compound 7) is a PDE4B/PDE7A inhibitor (PDE4B, IC50=80.4 μM) and 5-HT1A/5-HT-7R antagonist. PDE4B/7A-IN-1 has membrane-penetrating activity and high metabolic stability. PDE4B/7A-IN-1 exhibits antidepressant properties in rat behavioral tests[1].
CAS Number
2511632-25-8
UNSPSC
12352005
Target
5-HT Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pde4b-7a-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=CC=C1)N2CCN(CC2)CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O
Molecular Formula
C25H35N3O3
Molecular Weight
425.56
References & Citations
[1]Jankowska A, et al. Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. Eur J Med Chem. 2020 Sep 1;201:112437.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor; PDE4; PDE7

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