PDE4B/7A-IN-2

PDE4B/7A-IN-2

• CAS Number: 2511632-55-4
• UNSPSC Description: 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM) , its antidepressant like effect is stronger than that of escitalopram as a reference agent.
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/pde4b-7a-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(C=CC=C1)N2CCN(CC2)CCCCC(NC3=CC=C(C=C3)C(C)C)=O
• Molecular Weight: 409.56
• References & Citations: [1]Jankowska A,et al. Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. Eur J Med Chem. 2020 Sep 1;201:112437.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported