PDE4B/7A-IN-2

• CAS Number:

  2511632-55-4

• UNSPSC Description:

  5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM) , its antidepressant like effect is stronger than that of escitalopram as a reference agent.

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/pde4b-7a-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C=CC=C1)N2CCN(CC2)CCCCC(NC3=CC=C(C=C3)C(C)C)=O

• Molecular Weight:

  409.56

• References & Citations:

  [1]Jankowska A,et al. Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. Eur J Med Chem. 2020 Sep 1;201:112437.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported