PDE4B-IN-4

• Description:

  PDE4B-IN-4 (Compound 11E) is a PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM) inhibitor. PDE4B-IN-4 inhibits neutrophilia in a mouse lipopolysaccharide (LPS) -induced sepsis model and exhibits anti-inflammatory activity[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE) ; TNF Receptor

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C1NC(N/N=C/C2=CC=C(OC)C(OC)=C2)=NC(C3=CC(OC4CCCC4)=C(OC)C=C3)=C1C#N

• Molecular Formula:

  C26H27N5O5

• Molecular Weight:

  489.52

• References & Citations:

  [1]Almatary AM, et al. Dialkyloxyphenyl hybrids as PDE4B inhibitors: Design, synthesis, in vitro/in vivo anti-inflammatory activity and in silico insights. Bioorg Chem. 2025 Apr 25;161:108511.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE4