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PDE4B-IN-4

CAT: 0804-HY-172870Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-172870Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4B-IN-4 (Compound 11E) is a PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM) inhibitor. PDE4B-IN-4 inhibits neutrophilia in a mouse lipopolysaccharide (LPS) -induced sepsis model and exhibits anti-inflammatory activity[1].
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; TNF Receptor
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1NC(N/N=C/C2=CC=C(OC)C(OC)=C2)=NC(C3=CC(OC4CCCC4)=C(OC)C=C3)=C1C#N
Molecular Formula
C26H27N5O5
Molecular Weight
489.52
References & Citations
[1]Almatary AM, et al. Dialkyloxyphenyl hybrids as PDE4B inhibitors: Design, synthesis, in vitro/in vivo anti-inflammatory activity and in silico insights. Bioorg Chem. 2025 Apr 25;161:108511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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