Recombinant Mouse Siglec-3/CD33 Protein

• Description:

  Recombinant Mouse Siglec-3/CD33 Protein_x000D_ Catalog number: B2019060_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: 26.5 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’20°C_x000D_ Keywords: Cd33 Protein, Mouse; gp67 Protein, Mouse; Siglec-3 Protein, Mouse; Siglec3 Protein, Mouse_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Herrmann M, Krupka C, Deiser K, Brauchle B, Marcinek A, Ogrinc Wagner A, Rataj F, Mocikat R, Metzeler KH, Spiekermann K, Kobold S, Fenn NC, Hopfner KP, Subklewe M. Bifunctional PD-1 × αCD3 × αCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia Blood. 2018 Dec 6;132(23):2484-2494._x000D_ 2: Co MS, Avdalovic NM, Caron PC, Avdalovic MV, Scheinberg DA, Queen C. Chimeric and humanized antibodies with specificity for the CD33 antigen J Immunol. 1992 Feb 15;148(4):1149-54._x000D_ 3: Xu Y, Xu Q, Rosenblum MG, Scheinberg DA. Antileukemic activity of recombinant humanized M195-gelonin immunotoxin in nude mice Leukemia. 1996 Feb;10(2):321-6._x000D_ 4: Schwemmlein M, Peipp M, Barbin K, Saul D, Stockmeyer B, Repp R, Birkmann J, Oduncu F, Emmerich B, Fey GH. A CD33-specific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells Br J Haematol. 2006 Apr;133(2):141-51._x000D_ 5: Ulyanova T, Shah DD, Thomas ML. Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2 J Biol Chem. 2001 Apr 27;276(17):14451-8._x000D_ 6: Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, Biondi A, Biagi E, Bonnet D. Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo Leukemia. 2014 Aug;28(8):1596-605._x000D_ 7: Nikula TK, McDevitt MR, Finn RD, Wu C, Kozak RW, Garmestani K, Brechbiel MW, Curcio MJ, Pippin CG, Tiffany-Jones L, Geerlings MW Sr, Apostolidis C, Molinet R, Geerlings MW Jr, Gansow OA, Scheinberg DA. Alpha-emitting bismuth cyclohexylbenzyl DTPA constructs of recombinant humanized anti-CD33 antibodies: pharmacokinetics, bioactivity, toxicity and chemistry J Nucl Med. 1999 Jan;40(1):166-76._x000D_ 8: Jin DP, An A, Liu J, Nakamura K, Rockson SG. Therapeutic responses to exogenous VEGF-C administration in experimental lymphedema: immunohistochemical and molecular characterization Lymphat Res Biol. 2009;7(1):47-57._x000D_ 9: Cartellieri M, Feldmann A, Koristka S, Arndt C, Loff S, Ehninger A, von Bonin M, Bejestani EP, Ehninger G, Bachmann MP. Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts Blood Cancer J. 2016 Aug 12;6(8):e458._x000D_ 10: Caron PC, Schwartz MA, Co MS, Queen C, Finn RD, Graham MC, Divgi CR, Larson SM, Scheinberg DA. Murine and humanized constructs of monoclonal antibody M195 (anti-CD33) for the therapy of acute myelogenous leukemia Cancer. 1994 Feb 1;73(3 Suppl):1049-56. _x000D_ _x000D_ Products Related to Recombinant Mouse Siglec-3/CD33 Protein can be found at Proteins

• Short Description:

  Catalog Number: B2019060 (100 µg )_x000D_ Recombinant Mouse Siglec-3, also known as CD33, is a type I transmembrane protein expressed on myeloid cells. It mediates cell-cell interactions and regulates immune responses, playing a role in maintaining immune tolerance. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3