Recombinant Human Siglec-3/CD33 Protein

• Description:

  Recombinant Human Siglec-3/CD33 Protein_x000D_ Catalog number: B2019173_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: 27.4 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’20°C_x000D_ Keywords: CD33rSiglec Protein, Human; FLJ00391 Protein, Human; p67 Protein, Human; SIGLEC-3 Protein, Human; SIGLEC3 Protein, Human_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Romão E, Krasniqi A, Maes L, Vandenbrande C, Sterckx YG, Stijlemans B, Vincke C, Devoogdt N, Muyldermans S. Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33 Int J Mol Sci. 2020 Jan 2;21(1):310._x000D_ 2: Sarris AH, Talpaz M, Deisseroth AB, Estrov Z. Human recombinant interferon-inducible protein-10 inhibits the proliferation of normal and acute myelogenous leukemia progenitors Leukemia. 1996 May;10(5):757-65._x000D_ 3: Shaw BC, Estus S. Pseudogene-Mediated Gene Conversion After CRISPR-Cas9 Editing Demonstrated by Partial CD33 Conversion with SIGLEC22P CRISPR J. 2021 Oct;4(5):699-709._x000D_ 4: Jacobs SA, Foon KA. Monoclonal antibody therapy of leukaemias and lymphomas Expert Opin Biol Ther. 2005 Sep;5(9):1225-43._x000D_ 5: Angata T, Varki A. Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily Glycobiology. 2000 Apr;10(4):431-8._x000D_ 6: Cornish AL, Freeman S, Forbes G, Ni J, Zhang M, Cepeda M, Gentz R, Augustus M, Carter KC, Crocker PR. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33 Blood. 1998 Sep 15;92(6):2123-32._x000D_ 7: Takeshita A. Efficacy and resistance of gemtuzumab ozogamicin for acute myeloid leukemia Int J Hematol. 2013 Jun;97(6):703-16._x000D_ 8: Li N, Zhang W, Wan T, Zhang J, Chen T, Yu Y, Wang J, Cao X. Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells J Biol Chem. 2001 Jul 27;276(30):28106-12._x000D_ 9: Angata T, Varki A. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways J Biol Chem. 2000 Jul 21;275(29):22127-35._x000D_ 10: O'Hear C, Heiber JF, Schubert I, Fey G, Geiger TL. Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia Haematologica. 2015 Mar;100(3):336-44. _x000D_ _x000D_ Products Related to Recombinant Human Siglec-3/CD33 Protein can be found at Proteins

• Short Description:

  Catalog Number: B2019173 (100 µg )_x000D_ Recombinant Human Siglec-3, also known as CD33, is a protein from the sialic acid-binding immunoglobulin-like lectin family. It is expressed on myeloid cells and regulates immune responses, playing a role in immune cell signaling. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3