Cbl-b-IN-18

• Description :

  Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ligase Casitas B-lineage lymphoma proto-oncogene B (CPL-B) . Cbl-b-IN-18 inhibits the phosphorylation of CPL-B (IC50[1].

• UNSPSC :

  12352005

• Target :

  E1/E2/E3 Enzyme

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/cbl-b-in-18.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2=NC(C3CC3)=CC(C4=CC=C(F)C=C4C5=NN=CN5C)=C2)C=NC6=C1C=C(CN7C[C@@H](C)CCC7)C=C6C(F)(F)F

• Molecular Formula :

  C33H31F4N7O

• Molecular Weight :

  617.64

• References & Citations :

  [1]Murugan CHINNAPATTU, et al. Bicyclic heterocyclic compounds as cbl-b inhibitors. Worldwide, WO2024062363A1. 2023-09-18

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported