TK-129

TK-129

• CAS Number: 3031476-73-7
• UNSPSC Description: TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease[1].
• Target Antigen: Histone Demethylase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/tk-129.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N[C@H]1CN(C(C2=NNC(C(C)C)=C2)=O)CC1)NC3CC3
• Molecular Weight: 305.38
• References & Citations: [1]Tang K, et al. Discovery of Novel Pyrazole-Based KDM5B Inhibitor TK-129 and Its Protective Effects on Myocardial Remodeling and Fibrosis. J Med Chem. 2022 Sep 16.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported