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SB-414796

CAT: 0804-HY-123473Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123473Size:1 Each
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Description
SB-414796 is a selective, orally active and cross the blood-brain barrier dopamine D3 receptor antagonist with Ki values of 4, 400 nM for D3, D2, respectively[1][2].
CAS Number
264262-71-7
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-414796.html
Smiles
CS(C1=CC2=C(C=C1)CCN(CC2)CC[C@H]3CC[C@@H](CC3)NC(C4=CC=CC(C5=NOC(C)=N5)=C4)=O)(=O)=O
Molecular Formula
C29H36N4O4S
Molecular Weight
536.69
References & Citations
[1]Macdonald GJ, et al. Design and synthesis of trans-3- (2- (4- ((3- (3- (5-methyl-1,2,4-oxadiazolyl) ) - phenyl) carboxamido) cyclohexyl) ethyl) -7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796) : a potent and selective dopamine D3 receptor antagonist. J Med Chem. 2003 Nov 6;46 (23) :4952-64.|[2]Heidbreder CA, et al. Current perspectives on selective dopamine D (3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Ann N Y Acad Sci. 2010 Feb;1187:4-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; D3 Receptor

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MBS5774508SB-414796
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