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SB-408124

CAT: 0804-HY-70068-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-70068-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor[1].
CAS Number
288150-92-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/sb-408124.html
Purity
98.27
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(C)=NC2=C(C=C(C=C21)F)F)NC3=CC=C(C=C3)N(C)C
Molecular Formula
C19H18F2N4O
Molecular Weight
356.37
Precautions
H315, H319, H335
References & Citations
[1]Langmead CJ, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141 (2) :340-346.|[2]Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463 (4) :531-536.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX1 Receptor

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