Memantine-d6 (hydrochloride)

• Description:

  Memantine-d6 (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride) ) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with Kis of 0.51 nM and 94.9 μM, respectively[1].

• UNSPSC:

  12352211

• Target:

  Autophagy; Cytochrome P450; iGluR

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Purity:

  99.83

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]C ([2H]) ([2H]) [C@@] (C[C@@] (N) (C[C@@H]1C2) C3) (C1) C[C@@]32C ([2H]) ([2H]) [2H].Cl

• Molecular Formula:

  C12H16D6ClN

• Molecular Weight:

  221.80

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66 (11) : p. 1515-34.|[3]Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12 (11) : p. 4427-36.|[4]Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 (Pt 1) : p. 27-46.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1189713-18-5