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Toremifene-d6 (hydrochloride)

CAT: 0804-HY-B0005S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0005S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
Product Name Alternative
Z-Toremifene-d6 (hydrochloride) ; NK 622-d6 (hydrochloride) ; FC-1157a-d6 (hydrochloride)
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
ClCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)\C3=CC=C(C=C3)OCCN(C([2H])([2H])[2H])C([2H])([2H])[2H].[H]Cl
Molecular Formula
C26H23D6Cl2NO
Molecular Weight
448.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7 (Suppl 3) : S30-S35.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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