Products for Research Use Only
RegisterLogin

Memantine

CAT: 0804-HY-B0591-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0591-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD) [1][2][3].
CAS Number
19982-08-2
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/memantine.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
N[C@]12C[C@@]3(C)C[C@](C2)(C)C[C@@H](C1)C3
Molecular Formula
C12H21N
Molecular Weight
179.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25 (17) :4005. Published 2020 Sep 2. |[2]Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19. |[3]Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Biomedicines. 2022 Sep 22;10 (10) :2358.|bioRxiv. 2025 March 02.|Int J Mol Sci. 2024 Nov 19;25 (22) :12404.|Pharmacol Res Perspect. 2021 Oct;9 (5) :e00879.|Biomark Res. 2023 Aug 8;11 (1) :74.|Folia Neuropathol. 2023;61 (1) :25-36.|J Nanobiotechnology. 2025 Jun 16;23 (1) :445.|Neurochem Res. 2018 Oct;43 (10) :2008-2015.|Neuropharmacology. 2021 Feb 15:184:108443.

Chemical Information

Memantine

Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. It has a role as an antidepressant, an antiparkinson drug, a dopaminergic agent, a NMDA receptor antagonist and a neuroprotective agent. It is a primary aliphatic amine and a member of adamantanes. It is a conjugate base of a memantinium(1+). It derives from a hydride of an adamantane.

CAS Number19982-08-2
PubChem CID4054
IUPAC Name3,5-dimethyladamantan-1-amine
Molecular FormulaC12H21N
Molecular Weight179.30
XLogP3.3
Topological Polar Surface Area26
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count13
Formal Charge0
Complexity240
SMILES
CC12CC3CC(C1)(CC(C3)(C2)N)C
InChI
InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
InChIKey
BUGYDGFZZOZRHP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Memantine
CAS: 19982-08-2
CID: 4054
Formula: C12H21N
MW: 179.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight179.30
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass179.167399674
Monoisotopic Mass179.167399674
Topological Polar Surface Area26 Ų
Heavy Atom Count13
Formal Charge0
Complexity240
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3615956-01Memantine
CS-O-53657Memantine-d6
318183Memantine Hydrochloride
bs-82470C-01Memantine HCl
297545-01Memantine cellobiosyl-

Popular Products