Dronedarone-d6 (hydrochloride)

Dronedarone-d6 (hydrochloride)

• CAS Number: 1329809-23-5
• UNSPSC Description: Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].
• Target Antigen: Adrenergic Receptor; Autophagy; Calcium Channel; Cytochrome P450; Isotope-Labeled Compounds; mAChR; Sodium Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;GPCR/G Protein;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C(C2=C3)=C(CCCC)OC2=CC=C3NS(C)(=O)=O.Cl
• Molecular Weight: 599.25
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120(7):636-44.|[3]Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2):115-122.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported