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Dronedarone-d6 (hydrochloride)

CAT: 0804-HY-A0016SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0016SSize:1 mg
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Description
Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone , is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].
CAS Number
1329809-23-5
UNSPSC
12352005
Target
Adrenergic Receptor; Autophagy; Calcium Channel; Cytochrome P450; Isotope-Labeled Compounds; mAChR; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C(C2=C3)=C(CCCC)OC2=CC=C3NS(C)(=O)=O.Cl
Molecular Formula
C31H39D6ClN2O5S
Molecular Weight
599.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120 (7) :636-44.|[3]Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna) . 2019 Feb;126 (2) :115-122.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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