Memantine-d3 (hydrochloride)
CAT:
804-HY-B0591S
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Memantine-d3 (hydrochloride)
- CAS Number: 9007-83-4
- UNSPSC Description: Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].
- Target Antigen: iGluR; Isotope-Labeled Compounds
- Type: Isotope-Labeled Compounds
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling;Others
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Solubility: 10 mM in DMSO
- Smiles: N[C@]1(C2)C[C@]3(C)C[C@@H](C[C@@]2(C([2H])([2H])[2H])C3)C1.[H]Cl
- Molecular Weight: 218.78
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25(17):4005. Published 2020 Sep 2. |[3]Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273. |[4]Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported