Memantine-d3 (hydrochloride)

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Description

Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD) [1][2][3].

CAS Number

1329802-06-3

UNSPSC

12352211

Target

IGluR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

N[C@]1(C2)C[C@]3(C)C[C@@H](C[C@@]2(C([2H])([2H])[2H])C3)C1.[H]Cl

Molecular Formula

C12H19D3ClN

Molecular Weight

218.78

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25 (17) :4005. Published 2020 Sep 2. |[3]Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273. |[4]Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Chemical Information

Memantine-d3 Hydrochloride

CAS Number	1329802-06-3
PubChem CID	133587511
IUPAC Name	3-methyl-5-(trideuteriomethyl)adamantan-1-amine;hydrochloride
Molecular Formula	C12H22ClN
Molecular Weight	218.78
Topological Polar Surface Area	26
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Heavy Atom Count	14
Formal Charge	0
Complexity	240

SMILES

[2H]C([2H])([2H])C12CC3CC(C1)(CC(C3)(C2)N)C.Cl

InChI

InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/i1D3;

InChIKey

LDDHMLJTFXJGPI-NIIDSAIPSA-N

Chemical Structure

2D Structure

CAS: 1329802-06-3

CID: 133587511

Formula: C12H22ClN

MW: 218.78

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	218.78
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	218.1629076
Monoisotopic Mass	218.1629076
Topological Polar Surface Area	26 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	240
Isotope Atom Count	3
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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ESS0172-01	Memantine-D3 Hydrochloride
318183	Memantine Hydrochloride
ALX-550-363-M050	Memantine . hydrochloride
271411-01	Demethyl memantine hydrochloride
RM-M132037-01	Memantine-D6 Hydrochloride
RM-M132038-01	Memantine-D3 Hcl

Memantine-d3 (hydrochloride)

Chemical Information

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