GRB7 Recombinant Rabbit Monoclonal Antibody [JE50-05]

GRB7 Recombinant Rabbit Monoclonal Antibody [JE50-05]

• Description: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.
• Product Name Alternative: B47 antibody Epidermal growth factor receptor GRB 7 antibody Epidermal growth factor receptor GRB-7 antibody GRB7 adapter protein antibody GRB7 antibody GRB7_HUMAN antibody Growth factor receptor bound protein 7 antibody Growth factor receptor-bound protein 7 antibody OTTHUMP00000164349 antibody OTTHUMP00000164350 antibody OTTHUMP00000164351 antibody OTTHUMP00000164352 antibody
• Abbreviation: Growth factor receptor-bound protein 7 B47 Epidermal growth factor receptor GRB-7 GRB7 adapter protein GRB7
• CAS Number: 9000-83-3
• Swiss Prot: Q14451 Human
• Cellular Locus: Cell junction. Cell membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human GRB7 aa 1-150 / 532.
• Isotype: IgG
• Clone: JE50-05
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, FC
• Positive Control: A431 cell lysate, HepG2 cell lysate, SK-Br-3 cell lysate, human breast cancer tissue, human kidney tissue, SK-Br-3.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:500-1:2,000 ;IF-Cell: 1:100 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 60 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes