GRB7 Rabbit Polyclonal Antibody

GRB7 Rabbit Polyclonal Antibody

• Description: Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7, thought to be involved in migration[citation needed], is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
• Product Name Alternative: B47 antibody Epidermal growth factor receptor GRB 7 antibody Epidermal growth factor receptor GRB-7 antibody GRB7 adapter protein antibody GRB7 antibody GRB7_HUMAN antibody Growth factor receptor bound protein 7 antibody Growth factor receptor-bound protein 7 antibody OTTHUMP00000164349 antibody OTTHUMP00000164350 antibody OTTHUMP00000164351 antibody OTTHUMP00000164352 antibody
• Abbreviation: GRB7
• CAS Number: 9007-83-4
• Swiss Prot: Q14451 Human
• Cellular Locus: Cell membrane, Cytoplasm, Focal adhesion, Cytoplasmic granule, Cell projection.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human GRB7 aa 1-200/532.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB
• Positive Control: SK-Br-3 cell lysates.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 60 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No